Early adopters of the magical thinking cap: a study on do-it-yourself (DIY) transcranial direct current stimulation (tDCS) user community

Well done! Anita Jwa’s study of the DIY tDCS community is published. I would think this very useful to policy makers. I was only surprised by a few of her findings. Links below to full paper.

This study is the first empirical attempt to investigate the DIY tDCS user community. A questionnaire survey of DIY users, interviews with some active power users, and a content analysis of web postings on tDCS showed distinctive demographic characteristics of the DIY users, ambiguities and mistaken assumptions around the current state and future prospects of the DIY use of tDCS, mixed use of tDCS for both treatment and cognitive enhancement, the existence of an active self-regulating system in the community, and users’ demands for official guidelines and their concerns about government regulations on tDCS.

Source: Early adopters of the magical thinking cap: a study on do-it-yourself (DIY) transcranial direct current stimulation (tDCS) user community

Scientists retrieve lost memories using optogenetics

I’m exposing my bias here, which is the hope that tDCS will be found to facilitate memory retrieval. This study, in mice, retrieved dormant memories using light (optogenetics) to activate cells used in memory formation. Recent studies suggest that memories are formed within a synaptic network, parts of which extend to areas of the brain more frequently targeted by tDCS. Probably closest to the research I’d like to see done (that I’m aware of) was reported in 2009, “Where Are Old Memories Stored in the Brain?“. I imagine a study where early memory, triggered by photos and recollections, are imaged using fMRI and that later, those same areas are targeted using tDCS. In the study reported on above, Medial Temporal Lobe Activity during Retrieval of Semantic Memory Is Related to the Age of the Memory, researchers concluded that older memories associated with regions in the frontal lobe, temporal lobe, and parietal lobe. (Though seems inconclusive as to whether memories are ‘stored’ there… “An additional way to understand the increasing involvement of some cortical areas, especially frontal cortex, as time passes is that older memories require more strategic, effortful search.”) Now, back to the post title article…

The researchers then attempted to discover what happens to memories without this consolidation process. By administering a compound called anisomycin, which blocks protein synthesis within neurons, immediately after mice had formed a new memory, the researchers were able to prevent the synapses from strengthening.

When they returned one day later and attempted to reactivate the memory using an emotional trigger, they could find no trace of it. “So even though the engram cells are there, without protein synthesis those cell synapses are not strengthened, and the memory is lost,” Tonegawa says.

But startlingly, when the researchers then reactivated the protein synthesis-blocked engram cells using optogenetic tools, they found that the mice exhibited all the signs of recalling the memory in full.

“If you test memory recall with natural recall triggers in an anisomycin-treated animal, it will be amnesiac, you cannot induce memory recall,” Tonegawa says. “But if you go directly to the putative engram-bearing cells and activate them with light, you can restore the memory, despite the fact that there has been no LTP.”

Source: Scientists retrieve lost memories using optogenetics
See Also: Neuroanatomy of memory
Gone But Not Forgotten? The Mystery Behind Infant Memories
The Hippocampus and episodic memory
(video)
Neuron Basics (video)

Functional role of frontal alpha oscillations in creativity

Following up on the recent Flavio Frohlich paper. Some details here in the abstract about how the boost in creativity was achieved.

Frohlich-tACS

Creativity, the ability to produce innovative ideas, is a key higher-order cognitive function that is poorly understood. At the level of macroscopic cortical network dynamics, recent electroencephalography (EEG) data suggests that cortical oscillations in the alpha frequency band (8–12 Hz) are correlated with creative thinking. However, whether alpha oscillations play a functional role in creativity has remained unknown. Here we show that creativity is increased by enhancing alpha power using 10 Hz transcranial alternating current stimulation (10 Hz-tACS) of the frontal cortex. In a study of 20 healthy participants with a randomized, balanced cross-over design, we found a significant improvement of 7.4% in the Creativity Index measured by the Torrance Test of Creative Thinking (TTCT), a comprehensive and most frequently used assay of creative potential and strengths. In a second similar study with 20 subjects, 40 Hz-tACS was used instead of 10 Hz-tACS to rule out a general “electrical stimulation” effect. No significant change in the Creativity Index was found for such frontal 40 Hz stimulation. Our results suggest that alpha activity in frontal brain areas is selectively involved in creativity; this enhancement represents the first demonstration of specific neuronal dynamics that drive creativity and can be modulated by non-invasive brain stimulation. Our findings agree with the model that alpha recruitment increases with internal processing demands and is involved in inhibitory top-down control, which is an important requirement for creative ideation.

There’s a paywall to the full paper, but Kurzweil.net has the details.
Alpha-rhythm brain stimulation shown to boost creativity

Anodal tDCS over the Primary Motor Cortex Facilitates Long-Term Memory Formation Reflecting Use-Dependent Plasticity

Sham or anodal tDCS (1 mA) was applied for 20 min during motor practice and retention was tested 30 min, 24 hours and one week later. All subjects improved performance during each of the two sessions and learning gains were similar. Our main result is that long term retention performance (i.e. 1 week after practice) was significantly better when practice was performed with anodal tDCS than with sham tDCS. This effect was large  and all but one subject followed the group trend. Our data strongly suggest that anodal tDCS facilitates long-term memory formation reflecting use-dependent plasticity. Our results support the notion that anodal tDCS facilitates synaptic plasticity mediated by an LTP-like (long-term potentiation) mechanism, which is in accordance with previous research.

Transcranial Direct Current Stimulation of the Left Dorsolateral Prefrontal Cortex Shifts Preference of Moral Judgments

tDCS modified moral behavior! By ‘utilitarian’ I believe the researchers mean that the subject was less likely to ‘save the many’ by (actively participating in) sacrificing the few.

Accordingly, during anodal stimulation of the left DLPFC participants rated the utilitarian actions as more inappropriate than they did during sham and cathodal stimulation. Thus, anodal tDCS of the left DLPFC resulted in a shift of preference from an utilitarian, active decisions (i.e. to actively hazard another person’s life to rescue the lives of several people) to non-utilitarian, passive decisions (i.e. to avoid harming another person, but in consequence to accept the harm to several people.

For context, you might want to examine The Trolley Problem!

Understanding public (mis)understanding of tDCS for enhancement

Hey, we’re mentioned in a legit scientific journal! The article traces the evolution of tDCS in the public’s consciousness, and points out how sites like my own and the tDCS subReddit serve a valuable function in filtering information as presented in the general media, which often has a tendency to sensationalize soundbite takeaways from legit scientific papers. So chalk one up for citizen science and let’s hope this is a step along the way towards legit research that taps into the DIY communities. i.e. University-level research that creates methodologies for using DIY generated data.

The availability of tDCS as a consumer device, as well as the vivid online exchange of experiences with tDCS as well as instructions for DIY use (cf.: http://www.reddit.com/r/tDCS/; https://www.diytdcs.com) may be explanatory factors shaping the change in public attitudes towards tDCS, The observation that in the LATER PERIOD misunderstanding was reduced can be regarded as evidence that the public was developing a more mature understanding of tDCS. In view of the past trends, it appears important to inform the public accurately on the short- and long-term consequences of tDCS on healthy individuals and on the plausibility of enhancement effects. In addition, detailed knowledge of the current practice and prevalence of DIY tDCS is also needed.

Source: Understanding public (mis)understanding of tDCS for enhancement

Transcranial Direct Current Stimulation of Frontal Cortex Decreases Performance on the WAIS-IV Intelligence Test, Sellers 2015

[Update 5/15/15 More or less debunked, at least a much better understanding of the anomalies of this particular study, from Nathan Whitmore’s rebuttal.] Would only now like to see this replicated with tDCS applied during testing. i.e. In this study tDCS was administered prior to the test (‘offline’ as opposed to ‘online’). But for those of us who are looking to tDCS for potential cognitive enhancement, this is a significant study. Posted to Reddit by Gwern!

Transcranial direct current stimulation (tDCS) modulates excitability of motor cortex. However, there is conflicting evidence about the efficacy of this non-invasive brain stimulation modality to modulate performance on cognitive tasks. Previous work has tested the effect of tDCS on specific facets of cognition and executive processing. However, no randomized, double-blind, sham-controlled study has looked at the effects of tDCS on a comprehensive battery of cognitive processes. The objective of this study was to test if tDCS had an effect on performance on a comprehensive assay of cognitive processes, a standardized intelligence quotient (IQ) test. The study consisted of two substudies and followed a double-blind, between-subjects, sham-controlled design. In total, 41 healthy adult participants completed the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV) as a baseline measure. At least one week later, participants in substudy 1 received either bilateral tDCS (anodes over both F4 and F3, cathode over Cz, 2mA at each anode for 20 minutes) or active sham tDCS (2mA for 40 seconds), and participants in substudy 2 received either right or left tDCS (anode over either F4 or F3, cathode over Cz, 2mA for 20 minutes). In both studies, the WAIS-IV was immediately administered following stimulation to assess for performance differences induced by bilateral and unilateral tDCS. Compared to sham stimulation, right, left, and bilateral tDCS reduced improvement between sessions on Full Scale IQ and the Perceptual Reasoning Index. This demonstration that frontal tDCS selectively degraded improvement on specific metrics of the WAIS-IV raises important questions about the often proposed role of tDCS in cognitive enhancement.

Source: “Transcranial Direct Current Stimulation of Frontal Cortex Decreases Performance on the WAIS-IV Intelligence Test”, Sellers 2015 : tDCS

BBC – Future – Concentrate! How to tame a wandering mind (October 2014)

Not tDCS. It looks like TMS (Transcranial Magnetic Stimulation) but I’ve not heard of TMS being applied for more than short bursts before. Also of note in the article is the description of their target:

Their training programme targets the brain’s ‘dorsal attention network’, which links regions of the prefrontal cortex – the bit of the brain above the eyes that helps us make decisions – and the parietal cortex, the ‘switchboard’ for our senses, which is above and slightly behind the ears.

bbcConcentrate

(Caroline Williams)The pulses were aimed at my left prefrontal lobe, to dampen the activity there (Caroline Williams)When I get to the stimulation the next day, it’s not as bad as I feared. At least not at first. For the first minute or so it feels a bit like popping candy is going off under my skull. Five minutes in, though, and it’s seriously annoying – like the worst school bully ever repeatedly flicking me on the head.In all, I have two eight-minute-long sessions of magnetic stimulation, each followed by a 12-minute-long session of computer-based training. I also do three 12-minute blocks of training twice a day, over the internet, wherever my laptop and I happen to be.

Source: BBC – Future – Concentrate! How to tame a wandering mind

Augmentation of cognitive brain functions with transcranial lasers

I was inspired to revisit this paper today after reading a fascinating post on longecity.org by member, Lostfalco, an avid, one might venture to say extreme, proponent of self-experimenting. Here’s another very thorough post on Selfhacked.com by Joseph Cohen. And Gwern weighs in! Low-level light/laser therapy (LLLT) works in an entirely different way than tDCS. Feeling like I have a lot of reading ahead of me. I will begin to share more research as it becomes available. Check out the video below for a basic understanding of the process.

Cognitive and emotional functions
LLLT via commercial low-power sources (such as FDA-cleared laser diodes and LEDs) is a highly promising, affordable, non-pharmacological alternative for improving cognitive function. LLLT delivers safe doses of light energy that are sufficiently high to modulate neuronal functions, but low enough to not result in any damage.  In 2002, the FDA approved LLLT for pain relief in cases of head and neck pain, arthritis and carpal tunnel syndrome. LLLT has been used non-invasively in humans after ischemic stroke to improve neurological outcome. It also led to improved recovery and reduced fatigue after exercise. One LLLT stimulation session to the forehead, as reported by Schiffer et al. (2009), produced a significant antidepressant effect in depressed patients. No adverse side effects were found either immediately or at 2 or 4 weeks after LLLT. Thus, these beneficial LLLT treatments have been found to be safe in humans. Even though LLLT has been regarded as safe and received FDA approval for pain treatment, the use of transcranial lasers for cognitive augmentation should be restricted to research until further controlled studies support this application for clinical use.

via Augmentation of cognitive brain functions with transcranial lasers.

In this video LLLT is described as a treatment for damaged tissue. In the paper above, the same process is used to ‘augment brain function’.

Scientists Use Brain Stimulation to Boost Creativity

Flavio Frohlich photo Donn Young

Sounds like some kind of tACS. Will try to follow-up with more info.
See Also: Your Brain on Electricity

For the Cortex study, Frohlich’s team enrolled 20 healthy adults. Researchers placed electrodes on each side of each participant’s frontal scalp and a third electrode toward the back of the scalp. This way, the 10-Hertz alpha oscillation stimulation for each side of the cortex would be in unison. This is a key difference in Frohlich’s method as compared to other brain stimulation techniques.
Each participant underwent two sessions. During one session, researchers used a 10-Hertz sham stimulation for just five minutes. Participants felt a little tingle at the start of the five minutes. For the next 25 minutes, each participant continued to take the Torrance Test of Creative Thinking, a comprehensive and commonly used test of creativity. In one task, each participant was shown a small fraction of an illustration – sometimes just a bent line on a piece of paper. Participants used the line to complete an illustration, and they wrote a title when they finished.
In the other session each participant underwent the same protocol, except they were stimulated at 10 Hertz for the entire 30 minutes while doing the Torrance test. The tingling sensation only occurred at the start of the stimulation, ensuring that each participant did not know which session was the control session.
Because rating creativity or scoring a test can involve subjectivity, Frohlich sent each participant’s work to the company that created the test. “We didn’t even tell the company what we were doing,” Frohlich said. “We just asked them to score the tests.
”Then Frohlich’s team compared each participant’s creativity score for each session. He found that during the 30-minute stimulation sessions, participants scored an average 7.4 percentage points higher than they did during the control sessions.

via Scientists Use Brain Stimulation to Boost Creativity.
link to paper: (paywall) http://www.sciencedirect.com/science/article/pii/S0010945215001033

Longitudinal Neurostimulation in Older Adults Improves Working Memory | PLOS ONE

tdcsLongitudinalOlderAdults.jpg

Modeling of current flow when applying 1.5 mA tDCS for F4 anodal (top) and P4 anodal (bottom) stimulation and the cathodal electrode placed on the contralateral cheek.

Important study. 72 older participants, average age 64 showed improvement in working memory tasks but also (and this is a big deal where it comes to cognitive enhancement) significant transfer (where improvements are seen in other tasks not specifically trained for). These results run counter to other recent studies and beg the question of whether the participant’s age was a factor. i.e. Is tDCS more effective for aging brains? That would be a big deal. [See Also: tDCS selectively improves working memory in older adults with more education]  And thanks to PLOS ONE we can all read the full paper (linked below)

The results demonstrated that all groups benefited from WM training, as expected. However, at follow-up 1-month after training ended, only the participants in the active tDCS groups maintained significant improvement. Importantly, this pattern was observed for both trained and transfer tasks. These results demonstrate that tDCS-linked WM training can provide long-term benefits in maintaining cognitive training benefits and extending them to untrained tasks.

Interesting, the location of the reference (cathodal) electrode was opposite cheek.

In all conditions, one electrode was placed over the target location at either F4 or P4 (International 10–20 EEG system) and the reference electrode was placed on the contralateral cheek.

via PLOS ONE: Longitudinal Neurostimulation in Older Adults Improves Working Memory.

Keep Calm and Carry On: Improved Frustration Tolerance and Processing Speed by Transcranial Direct Current Stimulation (tDCS) | PLOS ONE

tdcsKeepCalmCC stands for cognitive control. In this study 28 participants took a PASAT test (try one yourself online the better you do the harder it gets). They also reported their state of mind, (PANAS) both before and after the PASAT test. Participants who received tDCS to dlPFC (dorsalateral prefrontal cortext) showed increased cognitive control and less stress from the test itself.

With this study, we provide first evidence that the enhancement of activity in the left prefrontal cortex by anodal tDCS during an adaptively challenging attention task improves performance parallel to, and in correlation with the suppression of specific task-induced negative affect. These data can be interpreted as a tDCS-supported shift of processing resources towards task-oriented performance away from preoccupation with task-related negative affect and cognition. Thereby they extend the notion of enhanced CC by prefrontal activation to internally generated distress-related distractors. More specifically, by demonstrating that tDCS-induced higher performance is associated with a lesser degree of feeling ‘upset’ with the task, these data may exemplify a subjective, experiential aspect of enhanced CC in challenging operations. Not least, these findings substantially support the concept of a tDCS-enhanced CC training as a new pathophysiology-based treatment approach of disorders associated with dysfunctional CC

tDCS seems to be (they say ‘might’), allowing our focus network to overpower the feedback network thereby shutting out the negative feedback (those self-doubting voices).

Since processing in the brain is highly competitive with different pathways mediating different aspects of information, the winners are those with the strongest sources of support [11]. Accordingly, increased activation of the dlPFC by anodal tDCS might strengthen its function to avert attention from affective reactions induced by performance errors and thus maintain goal-directed processing.

via PLOS ONE: Keep Calm and Carry On: Improved Frustration Tolerance and Processing Speed by Transcranial Direct Current Stimulation (tDCS).

New Products From Neuroelectrics

We met Neurolectrics in my first podcast interview with Ana Maiques. They created Enobio, a wireless multi-channel EEG cap, and Starstim, which adds tDCS (tRNS, tACS) alongside of EEG monitoring. They also make a powerful suite of software for controlling and monitoring their devices. They’ve recently added a few new products and some updates. They also have a blog!

New Stuff!
Enobio 32: EEG Cap now in 32 channels.
Neurosurfer: Combine 2D & 3D (inculding Oculus Rift support) Neurofeedback games.
Starstim Home Research Kit: Allows physicians to facilitate telemedicine tDCS sessions.
Starstim tCS: Starstim without EEG.
NUBE: Cloud data management for your tDCS and EEG studies. (Neuroelectrics has been distributing Starstim devices at the university research level for some years. We should assume they’ve collected a lot of fascinating data.)starstimNew
Neurosurfer Software in action:

https://www.youtube.com/watch?v=Uns3xAFpW_4

Nube Cloud Service:

https://www.youtube.com/watch?v=yv-NxHZ6MUg

 

Wearable functional near infrared spectroscopy (fNIRS) and transcranial direct current stimulation (tDCS) | Frontiers

This paper proposes combining tDCS with fNIRS (functional near infrared spectroscopy) for the purpose of monitoring effects of tDCS especially in the context of enhancing cognition, i.e. immediate and direct feedback that tDCS is ‘working’.

Using fNIRS to Monitor the Relationship of Cognitive Workload and Brain Dynamics fNIRS provides an attractive method for continuous monitoring of brain dynamics in both seated or mobile participants. fNIRS is safe, highly portable, user-friendly and relatively inexpensive, with rapid application times and near-zero run-time costs. The most commonly used form of fNIRS uses infrared light, introduced at the scalp, to measure changes in blood oxygenation as oxy-hemoglobin converts to deoxy-hemoglobin during neural activity, i.e., the cerebral hemodynamic response. fNIRS uses specific wavelengths of light to provide measures of cerebral oxygenated and deoxygenated hemoglobin that are correlated with the fMRI BOLD signal. Below we briefly review fNIRS studies of cognitive workload.

tDCS-fNIR2

via Frontiers | Wearable functional near infrared spectroscopy (fNIRS) and transcranial direct current stimulation (tDCS): expanding vistas for neurocognitive augmentation | Frontiers in Systems Neuroscience.

A framework for categorizing electrode montages in tDCS

Excellent! A new paper proposes a framework for talking about tDCS montages!

Figure 1. Subgroups of tDCS montages: (A) unilateral monopolar, (B) unilateral bipolar, (C) unilateral multiple monopolar, (D) bilateral bipolar-balanced, (E) bilateral bipolar-non balanced, (F) bilateral multiple monopolar, (G) midline monopolar, (H) midline bipolar-balanced, (I) midline bipolar-non balanced, (J) dual channel- bipolar, (K) dual channel midline double monopolar, (L) dual channel bilateral double monopolar.

Subgroups of tDCS montages