Ana Maiques of Neuroelectrics – DIY tDCS Podcast # 1

Well here we go! Episode one of the DIY tDCS podcast. Ana Maiques is co-founder (with Giulio Ruffini) of Spanish-based Starlab. Their spin-off company, Neuroelectrics makes Enobio, a research-quality wireless EEG device, and Starstim, a multi-channel wireless tcs & tDCS device. Download the interview here (zipped mp3). Show notes after the fold.

Ana Maiques of Starlab and Enobio

Ana Maiques of Starlab and Enobio

Ana Maiques wearing her Enobio

Ana Maiques wearing her Enobio

(If you speak Spanish you might enjoy the interview these photos were taken from.) Also, if you’re an EEG or tDCS researcher or clinician (or VC) on the East Coast, Ana is frequently in the New York and Boston area and is happy to discuss Enobio and Starstim. Neuroelectrics will be at the Advances in Mediation Research conference in NY Jan. 17 2013. (Schedule)  Check out the Neuroelectrics blog for excellent tDCS and EEG info.

Show Notes
Starlab is the parent company > Space (sensors) + Neuroscience
Cutting edge research > impact on society… products and services
Twelve years of research in neuroscience > Enobio, Starstim
Initial market is early adopters – researchers, clinicians and practitioners
Starstim (tDCS) > chronic pain, stroke rehabilitation (later… depression >> cognitive enhancement, addiction)
Medically certified in Europe and Canada
Filing 510k for Enobio in the US
Starstim has 8 channels for use as HD tDCS but can also use traditionally
Can also do tACS (alternating current), or random noise stimulation and at the same time Simultaneously record EEG
Can also use dry EEG electrodes
Roi Cohen Kadosh Oxford study, kids etc. (Link to video we discussed. NewScientist)
Study will determine if tDCS is efficacious in enhancing performance in certain areas (math)
Will have implications for people with Alzheimers
Partnerships with 15 hospitals doing research with Starstim
8 in U.S. and 7 in Europe. Different pathologies. Results to be published soon.
Post-stroke rehabilitation is a great place to see the effectiveness of tDCS
tDCS > Motor recovery… hand rehabilitation…
Can thereby measure the degrees of movement and improvement very objectively
Couple of groups showing very measurable results.
The Muse, Neurosky, Emotiv Home EEG devices?
Limitation is number of channels.
Started Enobio with 4 channels, but feedback from medical community lead to  developing a 20 channel Enobio.
For certain applications – games, BCI etc, the home EEG devices might be fine
But we’re looking at the medical application of EEG.
Doctors and researchers require the maximum coverage of the head.
Signal quality is very important.
EEG application
Emotion recognition, neural marketing, traumatic brain injury – concussion
BCI – wheelchairs.
Sponsoring a conference in NY on meditation. Sloan Kettering pre-chemo
medications >> less pain, better toleration of treatment.
Spanish VCs even more conservative since crisis
Patents >> cloud-based database recording experimental data
Software runs on a Mac.
We always said we want to be the Apple of neuroscience…”

Neuroelectrics Starstim

Starstim tDCS

Neuroelectrics Enobio

Enobio EEG

NIBS Non-Invasive Brain Stimulation – The Air Force Research Laboratory and tDCS

NIBS Non-Invasive Brain Stimulation

Every military application of tDCS I’ve seen so far specifically mentions drones and drone pilot training. This logo has a drone in it! For the record, I think the use of drones is illegal and immoral, and that the deaths of innocents is un-American and unacceptable. That said, the tDCS research coming out of this sector is fascinating and will no doubt have an impact beyond military training.

[Update 7/30/14 I’ve replaced the old (broken) link with an active one that comes via Ryan (see comment below)] http://colonyofcommodus.files.wordpress.com/2013/02/2012-afosr-review-mckinley.pdf it was a public document. It appears to be a set of slides used in a presentation. It documents the most aggressive use of tDCS for the purpose of learning and cognitive enhancement I’ve seen. You will conclude, after reading this, that the Air Force is not fooling around.

Air Force Research Laboratory Skill Learning tDCS

Here is one of the more shocking aspects of the research: The notion that cathodal stimulation can have a positive effect by depressing ‘competing memory’. What? The plot thickens.

Air Force Research Laboratory Skill Learning tDCS

There is weeks of research ahead for anyone diving deeply into this paper. A lot of new questions to answer.

tDCS Recent Activity 12/12 – 1/13

A lot of the ‘pop sci’ articles are drawing on the results of only a few studies. Hopefully we’ll get affirmation of the efficacy of tDCS in cognitive enhancement soon.

Does Passing A Small Current Through Your Brain Really Make You Smarter?

Excellent update from Giulio Ruffini of Neuroelectrics. Full of links to relevant papers.

tDCS and Stroke: What We Know So Far (Jan 2013)

As far as I can tell, this is a new development in understanding the mechanism for the mediation of pain using tDCS.

Immediate effects of tDCS on the μ-opioid system of a chronic pain patient
To our knowledge, we provide data for the first time in vivo that there is possibly an instant increase of endogenous μ-opioid release during acute motor cortex neuromodulation with tDCS.
(And the pop-sci media follow-up Electrical Current Can Unlock The Seriously Good Drugs In Your Brain and Happiness Is a Warm Transcranial Direct Current Electrode)

A lot of research is going on right now into understanding where exactly, current if flowing.

The electric field in the cortex during transcranial current stimulation
The aim of this study was to investigate the effect of tissue heterogeneity and of the complex cortical geometry on the electric field distribution.

Some context.

A pioneer work on electric brain stimulation in psychotic patients. Rudolph Gottfried Arndt and his 1870s studies.
Today’s brain stimulation methods are commonly traced back historically to surgical brain operations. With this one-sided historical approach it is easy to overlook the fact that non-surgical electrical brain-stimulating applications preceded present-day therapies.

Mental Practice, or MP is practicing doing something without actually doing it. A musician imagining playing their instrument for instance. This study measured quality of handwriting with the non-dominant hand while using tDCS.

Site-specific effects of mental practice combined with transcranial direct current stimulation on motor learning
In conclusion, our results suggest that MP-induced effects in improving motor performance can be successfully consolidated by excitatory non-invasive brain stimulation on the M1 and left DLPFC.

Marom Bikson’s ‘tDCS State of the Art’ Lecture Now On YouTube

There’s just so much going on in tDCS right now that it’s hard to keep track. Coupled with the fact that I don’t have a Uni account that lets me access new paper (although I’ve had some help there from time to time). One of my objectives is to understand what’s going on well enough to present you with an accurate overview of what’s new. But lately research papers are coming so quickly that it’s been overwhelming.

But here’s my take-away from Marom’s lecture: Electrode placement does not necessarily correlate with current flow! At least not the way one might assume. Watch the videos to get a clear picture.

 

Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory – Springer

[Update 12/17/2012 Another paper discussing the efficacy of using tDCS to enhance working memory. Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence]

Working memory, as associated with ‘brain training’ and ‘plasticity‘, is often expressed as what one would wish to have more of, or at the very least, what one hopes not to lose as we age. (For a great overview of working memory and the how’s of enhancing it, see this fascinating post from neuroscientist Bradley Voytek’s blog  Working memory and cognitive enhancement.)

Our aim was to determine whether anodal transcranial direct current stimulation, which enhances brain cortical excitability and activity, would modify performance in a sequential-letter working memory task when administered to the dorsolateral prefrontal cortex DLPFC. Fifteen subjects underwent a three-back working memory task based on letters. This task was performed during sham and anodal stimulation applied over the left DLPFC. Moreover seven of these subjects performed the same task, but with inverse polarity cathodal stimulation of the left DLPFC and anodal stimulation of the primary motor cortex M1. Our results indicate that only anodal stimulation of the left prefrontal cortex, but not cathodal stimulation of left DLPFC or anodal stimulation of M1, increases the accuracy of the task performance when compared to sham stimulation of the same area. This accuracy enhancement during active stimulation cannot be accounted for by slowed responses, as response times were not changed by stimulation. Our results indicate that left prefrontal anodal stimulation leads to an enhancement of working memory performance. Furthermore, this effect depends on the stimulation polarity and is specific to the site of stimulation. This result may be helpful to develop future interventions aiming at clinical benefits.

via Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory – Springer.
full pdf

This 2011 paper does confirm positive results of tDCS in a similar application and test setup. Improving working memory: exploring the effect of transcranial random noise stimulation and transcranial direct current stimulation on the dorsolateral prefrontal cortex.

However, the study does provide confirmation of previous findings that anodal tDCS enhances some aspects of DLPFC functioning.

PLOS ONE: Transcranial Direct Current Stimulation Augments Perceptual Sensitivity and 24-Hour Retention in a Complex Threat Detection Task

Vincent Clark is an author on this paper. He’s associated with the Mind Research Network. We earlier covered work by Michael Weisend, also from MRN around a Jan. 2012 paper. This paper offers further details and is available to the public.

Transcranial Direct Current Stimulation Procedures

TDCS was applied using an ActivaDose II Iontophoresis Delivery Unit, which provides for delivery of a constant low level of direct current. Square-shaped (11 cm2) saline-soaked (0.9% sodium saline solution) sponge electrodes were attached to the participant with self-adhesive bandage strips. The anode was placed near electrode site F10 in the 10-10 EEG system, over the right sphenoid bone. The cathode was placed on the contralateral (left) upper arm. The site of the anode was selected based on our previous fMRI results showing that this brain region was the primary locus of neural activity associated with performance this task [23].

Anodal 2 mA current was applied to the scalp electrode site F10 in the 10-10 EEG system. The resulting enhancement of performance in the threat detection task is consistent with our previous fMRI results [23] showing that the right inferior frontal cortex is a major locus of a distributed brain network that mediates performance on this task. The right parietal cortex is a part of this network and could also be a target for stimulation.
—————————–
One possible explanation for the improvement in detection performance (hit rate) in the threat detection task is that tDCS increases general arousal, thereby leading to a change in response bias in the more liberal direction [25], which would increase the hit rate. However, computation of signal detection metrics showed that there were no significant effects of tDCS on the ß measure of response bias. Instead, the effect of brain stimulation was to enhance perceptual sensitivity, d′.

The improvement in perceptual sensitivity suggests that participants receiving tDCS were better able to encode stimulus features that distinguished targets and non-targets, which in turn led to accelerated learning and improved retention.

via PLOS ONE: Transcranial Direct Current Stimulation Augments Perceptual Sensitivity and 24-Hour Retention in a Complex Threat Detection Task.

Behind Valkee: The Profitable Startup That Shines Lights Into Your Ears To Cure The Winter Blues | TechCrunch

We had a look at the Valkee earlier on the blog. I just bring it up again because it’s interesting that TechCrunch is covering it and pointing out its ‘successful startup’ aspect. I can’t imagine a DIY version of this could cost more than a few dollars.

“I told him you don’t need to your light your house. You need to light your brain,” Nissila said. The ear canal was the most natural and obvious way to shine light onto the surface of the brain. Within weeks, they had a prototype.

Called The Valkee, the device looks like an MP3 player with a set of fancy headphones attached to it. The earbuds actually have a pair of lights attached to them that run for 12-minute sessions at a time. The idea is that by shining light into sensitive areas of the brain, it will stimulate a special OPN3 protein in parts of the brain that help regulate serotonin, melatonin and dopamine production.

They’re initially marketing it to people with Seasonal Affective Disorder, but they’re planning to expand their consumer base to people who need to fight off jet lag.

“If I stop using it for one week, I start eating more and it becomes very difficult to wake up in the morning,” said Timo Ahopelto, who was CEO of the company before leaving to join early-stage Finnish VC fund Lifeline Ventures, which also holds a stake in Valkee. I’ve used it, and I can’t tell if there is any effect yet beyond making my ears feel warm in the morning. But I’m also Californian, so I’m not even really sure I suffer from seasonal affective disorder because we don’t really have seasons.

http://www.youtube.com/watch?v=-BA2VeFByqc

via Behind Valkee: The Profitable Startup That Shines Lights Into Your Ears To Cure The Winter Blues | TechCrunch.

Dave Siever – Mind Alive Revisited

We met Dave earlier on the blog. His company, Mind Alive Inc. operates out of Edmonton, Canada and sells a wide variety of ‘mind machines‘, including the Oasis Pro, which can be used for tDCS. Medical devices are controlled differently in Canada, the EU, and the U.S. About tDCS devices…

In Canada, it is not considered a medical device when used in a cognitiveneuroscience application.

I need to do a deep dive with an expert at some point, but for now, let’s operate under the assumption that it’s much easier to get a tDCS device in Canada or Europe. According to the Mind Alive ordering page, there does not seem to be anything special or awkward about ordering one of their devices. (I have no affiliation with Mind Alive).

Here Dave gives an overview of tDCS, how it’s theorized to work, and includes a set of tDCS montages for various purposes. Excellent!

 

Is tDCS Safe? – Neuroelectrics.com

This comes to us via the Neuroelectrics.com blog. I’m very excited to see Neuroelectrics on the scene. I first noticed their device Starstim (pictured),  popping up in news around Roi Cohen Kadish’s ongoing tDCS trials at his Oxford lab (see). I believe Neuroelectrics is a Spanish company. What’s especially exciting to me is that they also make an EEG device called Enobio and are working on the ability to map brain activity with EEG while undergoing tDCS. Think about that! Live, in-the-moment feedback on exactly what effect your tDCS is having.

More than 100 studies have been performed using tDCS in healthy controls and in patient populations, and no serious side effects have occurred for a review, see Nitsche and others 2008. Slight itching under the electrode, headache, fatigue, and nausea have been described in a minority of cases in a series of more than 550 subjects Poreisz and others 2007. Detailed studies have been performed to assess the safety of tDCS. These have shown that there was no evidence of neuronal damage as assessed by serum neuron-specific enolase after application of a 1 mA anodal current for 13 minutes Nitsche and Paulus 2001; Nitsche, Nitsche, and others 2003 or MRI measures of edema using contrast-enhanced and diffusion-weighted MRI measures after application of a 1 mA current for 13 minutes anodal or 9 minutes cathodal; Nitsche, Niehaus, and others 2004 […] In addition, a recent study was performed in rats using an epicranial electrode montage designed to be similar to that used in tDCS Liebetanz and others 2009. This demonstrated that brain lesions occurred only at current densities greater than 1429 mA/cm2 applied for durations longer than 10 minutes. In standard tDCS protocols in humans, a current density of approximately 0.05 mA/cm2 is produced.

More about the Neuroelectrics Enobio EEG device.

http://www.youtube.com/watch?v=fg_w6wPehss

via Is tDCS Safe?.

tDCS – Building Research tDCS Units « SpeakWisdom

This bubbled up today. He explores some choices he made in building his DIY kit in a series of blog posts on tDCS.

Just to see how easily it could be done, I built a couple of tDCS units for about $30 each using common parts. The meters were purchased from EBay for about $7 each and all the remaining components came from a local Radio Shack, including the case, voltage regulator, resistors, etc. The tDCS units feature a potentiometer to make it possible to adjust current for treatment specifics or pad variations.

20120902-214144.jpg
(Two tDCS units built in about 3 hours for well less than $100)

 

via tDCS – Building Research tDCS Units « SpeakWisdom.

If She Were Your Daughter – Ritalin, Adderall or tDCS?

Update 11/18/12 New Scientist has just posted a video showing (I believe) the device and test that will be used in Roi Cohen Kadosh’s upcoming study to study the efficacy of tDCS to enhance math abilities. Brain-zapping Kinect game boosts mathematical skills

The recent PBS article Boosting Kids’ Brain Power nicely documents the work of University of Oxford’s Dr. Roi Cohen Kadosh in testing and developing protocols for improving math and learning skills with tDCS. Through interviews, PBS follows the thinking of parents exploring the possibility of using tDCS to help their kid’s difficulties with learning math. One parent compares the possible harms of tDCS vs. pharmaceutical approaches and I think this is the key question. You can listen to the piece on the article page, or download the mp3 here.

The PBS story follows a trend on the uptick: Brain enhancement and the ethics thereof.  In How Science Can Build a Better You, David Ewing Duncan tells us:

Over the last couple of years during talks and lectures, I have asked thousands of people a hypothetical question that goes like this: “If I could offer you a pill that allowed your child to increase his or her memory by 25 percent, would you give it to them?”

The show of hands in this informal poll has been overwhelming, with 80 percent or more voting no.

Then I asked a follow-up question. “What if this pill was safe and increased your kid’s grades from a B average to an A average?” People tittered nervously, looked around to see how others were voting as nearly half said yes. (Many didn’t vote at all.)

“And what if all of the other kids are taking the pill?” I asked. The tittering stopped and nearly everyone voted yes.

Another NY Times article Risky Rise of the Good-Grade Pill points out the extent to which kids are already using pharmaceuticals, illegally, to enhance brain power.

The boy exhaled. Before opening the car door, he recalled recently, he twisted open a capsule of orange powder and arranged it in a neat line on the armrest. He leaned over, closed one nostril and snorted it.

Throughout the parking lot, he said, eight of his friends did the same thing.

The drug was not cocaine or heroin, but Adderall, an amphetamine prescribed for attention deficit hyperactivity disorder that the boy said he and his friends routinely shared to study late into the night, focus during tests and ultimately get the grades worthy of their prestigious high school in an affluent suburb of New York City. The drug did more than just jolt them awake for the 8 a.m. SAT; it gave them a tunnel focus tailor-made for the marathon of tests long known to make or break college applications.

All of this points to an alarming skewing of culture and values I have no business addressing. It is easy for me to say however, that if my son or daughter were facing issues around attention or learning abilities, I’d certainly want the option of a proven, effective, and safe tDCS treatment before I’d consider a pharmaceutical approach.

To that end I wish Roi Cohen Kadish and his team at Oxford the best in their ongoing trials. See Also: Electrical brain stimulation improves math skills New Scientist
‘Human enhancement’ comes a step closer BBC
Brain stimulation ‘not a magic pill’ BBC Audio
The ethics of brain boosting Oxford

Safety – Transcranial direct current stimulation tDCS

Excellent overview article on tDCS from University of Munich who have a research group devoted to Transcranial brain stimulation and neuroplasticity.

Safety of the method
Several studies have been performed on the safety of tDCS and on side effects and have resulted in clear recommendations on its safe use. There is general agreement that if attention is paid to recommendations concerning contraindications and stimulation parameters, tDCS is a well tolerated method with minimal side effects Nitsche et al. 2003, Fregni et al. 2006, Iyer et al. 2005.
The physiological changes involve the modulation of spontaneous neuronal activity through polarity-specific shifts of the resting membrane potential in the direction of de- or hyperpolarisation. The direction of the change is governed by the direction of current flow, the spatial orientation of the neuron, the type of neuron and the total charge. This underlies the possible complication of inducing an epileptic seizure. In accordance with the safety protocol from Nitsche and Paulus 2000, the stimulation charges used here lie far below the charges necessary to trigger a seizure. Even a continuous stimulation just below the energy threshold for triggering a seizure was associated with only a 40% increased cortical excitability compared with baseline. Studies on the question of whether neuronal damage can be observed after tDCS and whether structural changes occur in the brain revealed no indications of damaging effects of tDCS. Thus, levels of neuron-specific enolase NSE, a marker for neuronal destruction, were not increased after tDCS Nitsche et al. 2003 and pathological changes could not be found in either contrast-enhanced MRT or in EEG Nitsche 2003.
Persistent disorders of motor and cognitive abilities have not been found. Electrically induced local muscle contractions during the stimulation can be unpleasant for the person undergoing tDCS. The electrical stimulation causes irritation of the scalp lasting just a few seconds, which has been described as more or less painful tingling and pulling Fregni et al. 2006. Cortical tissue damage has not been found, even after high stimulation intensities and frequencies. Stimulation with electrodes on the scalp could indeed result in a chemical reaction and in burning of the skin tissue. However, the risk of a skin burn is minimised if sponge electrodes soaked in salt water are used, in accordance with the safety protocol of Nitsche and Paulus 2000.
Fregni et al. did not describe any side effects in their studies Bip Disorders 2006, Clin Neurophysiol 2006, Depr and Anx 2006; the treatment was well tolerated by all the patients.

via Transcranial direct current stimulation tDCS.