Coming Soon—Electronic Mood Control | MIT Technology Review

 

If Tyler is right, it could explain why tDCS results have been so hard to replicate. Researchers position tDCS electrodes based on the assumption that they affect the areas of the brain directly below. But sometimes they may be accidentally stimulating the cranial nerves instead, leading to inconsistent results. Based on his new hypothesis, Tyler changed where he placed the electrodes, targeting these nerves specifically.

Early experiments showed enough of an effect to suggest the hypothesis was right, Tyler says. But the effects weren’t huge. The next step was to amplify the effect by increasing current levels without causing pain or skin damage. Researchers at Thync, which was founded in 2011, did this in part by using pulses of electricity, rather than steady current, and operating at frequencies that don’t stimulate pain receptors.

I experienced the difference that these measures make when I tried out a conventional tDCS device side-by-side with Thync’s technology. At three or four milliamps of electrical current, conventional tDCS was quite painful. That’s why most experiments are done at around one milliamp. In contrast, I couldn’t even feel the pulses from Thync’s device at 10 milliamps.

via Coming Soon—Electronic Mood Control | MIT Technology Review.

Tapping into the power of Thync | TechRepublic

Very well-written and detailed article on the upcoming Thync device. Links to full article below.

I set the vibe level to 60, and felt a slight pressure on my forehead as the vibe commenced. It wasn’t painful but I did note an almost immediate change as the calming electrical signals began to enter my brain. This wasn’t a placebo and it wasn’t suggestion: it was real.

“Think about a stressful situation,” Sumon advised. “Then focus on it a bit later to see how you react to it.”

Naturally, I thought about the hike back to my car and the exodus from Boston before rush hour commenced. Already the apprehension that previously seemed to be looming was a mere thought, nothing more. Just a few moments after starting the demo I felt a steady flow of relaxation coursing through my body. It was a bit like tubing down a lazy river at a water park; pleasant and entertaining, yet not too intense. I continued to take notes on my reactions as Sumon worked on his computer. It was like a comfortable visit with a colleague I’d known for a while.

“You may feel some euphoria,” Sumon stated. I agreed; the experience was like the buzz of a couple of beers, minus the “belly glow” that goes with it.

I raised the intensity level to 62, then 64 and finally 68. I noticed when I increased the threshold I felt a slight twist of pressure in my temple as the sensor responded, but it wasn’t uncomfortable or distracting. However, 68 represented a euphoric flow a bit higher than I seemed to need, so I dialed back down to 62.

I reflected on my upcoming drive home and felt nothing other than confidence. The car would be fine where I had parked it and the drive would be okay too. Even if things got sticky, I had the radio to listen to and no particular demands on my schedule for the evening. There were far worse things than sitting in Boston traffic, I reflected absently.

via Tapping into the power of Thync – TechRepublic.

Brain injury allows man to visualize the world Matrix-style | TechGenMag

The fMRI scan revealed increased activity in the left hemisphere of Padgett’s brain, which is where mathematical skills are thought to originate. Another area in Padgett’s brain that lit up was the left parietal cortex, a region responsible for integrating information coming from different senses. Brogaard’s team also used a transcranial magnetic stimulation (TMS) as a way to pinpoint the exact location of Padgett’s synesthesia. The TMS involves directing a magnetic pulse at a desired part of the brain, which either activates or inhibits a specific region. The results of the TMS experiment showed that when zapping Padgett’s parietal cortex, his synesthesia could be turned on and off.

via Brain injury allows man to visualize the world Matrix-style.

Three things to know before trying tDCS — tDCS and Neurodynamics — A Modern Monk

Again, the takeaway message for me being, ‘your mileage may vary’ and, ‘are you sure it’s doing what you think it is?’.

In my experience, the best way to determine whether tDCS was effective was through stimulating the visual cortex and playing a vision training game called Ultimeyes for the iPad. I came across this study (http://www.ncbi.nlm.nih.gov/pubmed/18491714) when I first started reading about tDCS and thought I would try it myself. After just one session, I could clearly see the difference in my ability to perceive low contrast objects in the app, and this carried over to recognizing features and objects outside as well, and especially in low light conditions.

via Three things to know before trying tDCS — tDCS and Neurodynamics — Medium.

Neurostimulation: Hacking your brain | The Economist

Very well researched and well-balanced article from Mark Harris at The Economist.

Hardly surprising, then, that DIY brain hackers want in on the action. Christopher Zobrist, a 36-year-old entrepreneur based in Vietnam, is one of them. With little vision he has been registered as blind since birth due to an hereditary condition of his optic nerve that has no established medical treatment. Mr Zobrist read a study of a different kind of transcranial stimulation (using alternating current) that had helped some glaucoma patients in Germany recover part of their vision. Despite neither the condition nor the treatment matching his own situation, Mr Zobrist decided to try tDCS in combination with a visual training app on his tablet computer. He quickly noticed improvements in his distance vision and perception of contrast. “After six months, I can see oncoming traffic two to three times farther away than before, which is very helpful when crossing busy streets,” he says.

Equally troublesome is a meta-analysis of the cognitive and behavioural effects on healthy adults that Mr Horvath subsequently carried out. As before, he included only the most reliable studies: those with a sham control group and replicated by other researchers. It left 200 studies claiming to have discovered beneficial effects on over 100 activities such as problem solving, learning, mental arithmetic, working memory and motor tasks. After his meta-analysis, however, tDCS was found to have had no significant effect on any of them.

If tDCS alters neither the physiology of the brain nor how it performs, thinks Mr Horvath, then evidence suggests it is not doing anything at all. Marom Bikson, a professor of biomedical engineering at City University of New York, disagrees. “I can literally make you fall on your butt using the ‘wrong’ type of tDCS,” he says. Dr Bikson thinks the biggest challenge for tDCS is optimising techniques, such as the dose.

via Neurostimulation: Hacking your brain | The Economist.

Modulating and enhancing cognition using brain stimulation: Science and fiction | Roi Cohen Kadosh

Roi Cohen Kadosh is a leading non-invasive brain stimulation researcher. (Also elsewhere on the blog)

A new line of research opens the possibility of modulating and enhancing human cognition using mild and painless transcranial electrical stimulation (tES), which includes transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS). Such initial findings trigger excitement as well as scepticism. The current review aims to provide a guideline for those who are interested in expanding their research into this field. I will therefore discuss: (1) the principles of tES and its putative mechanisms; (2) its potential to modulate and enhance cognitive abilities; (3) the misconceptions on which scepticism about this method is based; and (4) possible directions for the advancement of this field in which psychologists in general and cognitive psychologists in particular should in my view play a key role. I will conclude that this nascent field, which has been neglected by psychologists, requires their contribution in order to lead to basic and translational advancements on human behaviour.

And another excerpt around the hot topic of ‘transfer’… Basically, that it’s difficult to measure (positive effects of stimulation leading to enhanced intelligence) when we’re not even sure what cognition means.

Transfer effects
Another closely related issue in cognitive enhancement and training is the issue of transfer (Taatgen, 2013). Currently, there is mixed evidence from tES-paired training studies of transfer of tES-training benefits to another task. One of the issues regarding this lack of consistency is the difficulty of selecting appropriate training and transfer tasks, and this in my view is often due to a difficulty in identifying which cognitive functions and brain regions are activated by the specific training material. In other words, the constraint might not be due to the limited potential of tES to induce transfer, but due to suboptimal experimental design. This drawback is not limited to tES, but is a generic problem in the field of rehabilitation and cognitive enhancement (Cohen Kadosh, 2014). Indeed, some studies have shown that tES can even further increase the chance of transfer in paradigms that have struggled to show transfer without stimulation (Cappelletti et al., 2013; Looi, Duta, Huber, Nuerk, & Cohen Kadosh, 2013). Further studies are needed to examine the multifaceted issue of transfer effects, and their possible enhancement using tES. However, in order for such knowledge to progress, a better understanding of the cognitive mechanisms involved is necessary (Taatgen, 2013).

via Taylor & Francis Online :: Modulating and enhancing cognition using brain stimulation: Science and fiction – Journal of Cognitive Psychology – Volume 27, Issue 2.
direct pdf download

ApeX Type A Device

[Update 2/28/15] I’ve been re-stacking the post order lately around whatever seems especially significant or interesting. This is the only device I’ve seen so far with dual electrode (sets of) capacity and I’m curious to hear if anyone has used the ApeX device.]

A device I’ve not seen previously. Looks to be simple to understand and well-crafted. Will have to wait for the Redditors to take it apart to know what’s inside. Looks like a one man operation, Claude Barreto. Reasonably priced as well. Interesting that you have to agree to the Terms and Conditions of Sale before you can get to the order form. I’m intrigued by the dual electrode option. That one could apply tDCS to two locations simultaneously is, I think, new for any of the DIY-level tDCS devices. [I am not affiliated with this or any other device mentioned on the site.]
Website: http://www.apexdevice.net/

The Brain Stimulator tDCS Travel Model

Brain Stimulator just announced their new ‘Travel Model’.

tDCS Portable Travel Model with Coin

Complete Package for the tDCS Travel ModelPortable tDCS Travel Model - Side ViewView of the electrode Jack for the tDCS Travel ModelInternals of The Brain Stimulator Travel ModelPocket Sized Portable tDCS DevicePocket Sized Portable tDCS Travel Model

$59.95$110.00

Now Available!

The smallest, lightest, and most affordable tDCS device is finally here. Looking for a portable tDCS option? Something you can slip in your pocket and can go anywhere with you? Or looking to just try out tDCS to see if it’s right for you? The Brain Stimulator tDCS Travel Model may be the answer for you!

This device features a switch that allows you to access “high” and “low” (2mA and 1mA) settings, a convenient electrode jack on the top, 3 feet of electrode wires, and a smooth small design capable of going almost anywhere. (Note 9V battery not included)

via The Brain Stimulator tDCS Travel Model.

Foc.us Firmware – Still to Come…

A string of Foc.us news and updates over the last few days warrants our attention. Again, I’m very impressed with these announcements. Someone sat down and got very serious about creating a device/software that would fulfill everyone’s home use tDCS wish list. (Note: Have yet to see feedback from anyone actually using or having tested the Foc.us vs2 firmware upgrade yet. Will report when I do.) From the Foc.us blog. Upcoming features:

Here is an outline list of the features we will be adding to the foc.us firmware over the next few weeks

  • Calibrate – find your current and voltage for each mode
  • Save, share and download new programs
  • Motion sensor – activity tracking capability
  • Customisations – device name, pin, lock mode
  • Games – nback, dual n-back, arrow game
  • Bluetooth Low Energy support for new iOS and Android apps
  • Realtime Clock – ability to set session start time in the future
  • Vibro buzzer feedback
  • Multilingual translations

Amrex-type electrode support:
focusAmrexAdaptor

And a detailed description of the thoughts around security and what goes into their firmware updates. Impressed!

via FOC.US — foc.us firmware – still to come….

Will 2015 Be The Year Our Smartphones Link Up To Our Brains? | Popular Science

As executive director Sumon Pal fixes two small electrodes to my head he waxes poetic about that science. Writing vibes, he says, is like writing songs. “You figure out the pieces you want, but things change over time.” Over the next 16 minutes, things do change. My head and neck become accustomed to the warm vibrations imparted by the electrodes. My breathing slows noticeably, my thoughts cease their usual ricocheting off one another and zero in on the moment, and the familiar knot of tension between my shoulder blades begins to soften. By the time the Calm Vibe has run its course, the feeling feeling of warm relaxation running through me is somewhat analogous to the sensation one feels after a short bout of meditative yoga—or perhaps a healthy snort of bourbon.

The company is confident that before the end of the year it will be selling a consumer-friendly piece of wearable tech that actively alters users’ biology. Users will enhance their mental state with the swipe of a finger. It’s not science fiction anymore, Tyler says. It’s just science.

via Will 2015 Be The Year Our Smartphones Link Up To Our Brains? | Popular Science.

How the first brain-altering wearable is being tested | TheDailyDot

Here we go. The Thync device isn’t tDCS after all.
From the study:

Abstract
We have developed a neuromodulation approach that targets peripheral nerves and utilizes their afferents as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) approach on physiological responses to acute stress induction. TEN was targeted to the ophthalmic and maxillary divisions of the right trigeminal nerve and cervical spinal nerve afferents (C2/C3) using high-frequency, pulse-modulated electrical currents. Compared to active sham stimulation, TEN significantly suppressed sympathetic activity in response to acute stress without impeding cognitive performance. This sympatholytic action of TEN was indicated by significant suppression of heart rate variability changes, galvanic skin responses, and salivary α-amylase levels in response to stress. These observations are consistent with the hypothesis that TEN acted partially by modulating activity in the locus coeruleus and subsequent noradrenergic signaling. Dampening sympathetic tone using TEN in such a manner represents a promising approach to managing daily stress and improving brain health.

And as reported by Daily Dot

While I had only 30 minutes of time with Thync, the team told me that it’s been doing in-depth beta testing for a while. Now, Thync is starting to release some of its findings. In a press release this morning, Thync announced a study showing that its device reduces stress without chemicals. Here’s a quick look at how it worked:

In the study, researchers experimentally induced stress in subjects by exposing them to various environmental stimuli causing fear or cognitive pressure. When Thync scientists examined stress biomarkers in the saliva of subjects at different time points throughout the study, they observed something interesting. They found the levels of salivary α-amylase, an enzyme that increases with stress, as well as noradrenergic and sympathetic activity, significantly dropped for the subjects that received electrical neurosignaling compared to the subjects that received the sham.

The results are exactly what Thync has been saying: That it can de-stress us without putting anything into our bodies. It’s an interesting (though admittedly, very academic) look at how Thync works. But the company also helped me understand its testing and offered an anecdotal look at how the device is being used.

via How the first brain-altering wearable is being tested.

Ladies and Gentlemen, The Intellihat

My previous post about a patent I stumbled on has led me today to discover the Intellihat! Searching the patent authors Jeffrey Edward Arle and Jay Lawrence Shils landed me on the Home page of Intellihat, tagline. Gently Stimulate Your Brain™. And I get it! Classic American entrepreneurship.

Intellihat-Stone-FrontView

intellihatInventors

Intellihat was founded by two pioneers in the booming field of neuromodulation, Jeffrey E. Arle, M.D., Ph.D. (center), and Jay L. Shils, Ph.D. (right). Neuromodulation is the use of mild electric fields to stimulate the nervous system. In addition to authoring over 150 research papers, Dr. Arle and Dr. Shils are the editors of and contributing authors to Essential Neuromodulation, a reference book of articles by leaders in the field. Kris Carlson (left) runs the computer simulations that study how the Intellihat works and how to improve it.

A couple of neurology PHDs apply their expertise and a moderate investment to create a consumer product that could make some serious money. Forgive the attitude in my previous post around the patent. If you’re going to invest your time and money in inventing something, of course you’re going to want to protect it, and as broadly as possible. So no more patent troll references (and fingers crossed they’re not).

The device targets the Dorsal Lateral Prefrontal Cortex (DLPFC).
Of special interest: “The Intellihat contains a transmitter and two flat antennas placed above your temples. The antennas are made of antibacterial silver cloth and send a low-power, low-frequency signal into your DLPFC, mildly stimulating it.

intellihat2

intellihat3
I’d expect we’ll hear some intelligent assessment of this board from some of the folks on the tDCS Subreddit.
intellihat

And finally, you can buy one! In fact, it looks like you could be the first to do so!
http://www.bonanza.com/items/like/124487491/Intellihat-Gently-Stimulate-Your-Brain

In all sincerity I wish them the best and look forward to better understanding their device and its effects.